CVI Director Dr. Nora Disis spoke with Karina Vargas from KOMO4 news about the findings of our Phase I clinical trial with a HER2 ICD DNA vaccine recently published in JAMA oncology. The vaccine was administered in women with advanced stage HER2 positive breast cancer, 3 times one month apart, in a dose escalation study. A total of 66 patients received one of three doses and were followed for about 10 years post-vaccination. The key findings of the study are that (1) the vaccine is safe with only mild side effects, (2) all three doses elicited an immune response, and (3) 80% of patients who received the median dose are still alive 10 years after vaccination and 70% of patients who received the lower and higher doses are still alive after 10 years.
You can watch the video and interview with Dr. Disis here: https://komonews.com/news/local/university-of-washington-school-of-medicine-researchers-enter-next-phase-of-breast-cancer-vaccine-seattle-huskies